A Comparison of the Effects of Twelve Weeks Combined Training with Different Ordering on CTRP3, TNF-α, IL6 and Insulin Resistance in Women with Type 2 Diabetes

Introduction: The purpose of the present study was to investigate the effect of twelve weeks of combined exercise training on CTRP3, TNF-α, IL6 and insulin resistance in women with type 2 diabetes. Materials and Methods: Thirty-six patients were divided into three groups, i.e. The control group (38.20±3.11 years), the aerobic-resistance combined exercise group(37.63±3.69 year) and the resistance aerobic combined exercise group(38.77±3.3 years). The training program for the combined exercise groups consisted of aerobic exercise with 80 to 95% maximal heart rate, resistance training with 60 to 85% 1RM intensity for 12 weeks (three sessions per week) with different anthropometric variables and levels. Serum TNF-α, IL6, CTRP3 and insulin resistance index were measured before and after exercise. Analysis of variance was performed using 2-way repeated measures of ANOVA and the significance level was set at <0.05. Results: The main effect showed a significant decrease in serum levels of TNF-α (p=0.001), IL6 (p=0.001) and a significant increase in CTRP3 in the training group (p=0.001). The interactive effect differed significantly between training groups in the post-test, compared to the control group (p=0.001), whereas the changes were similar between training groups. (P=0.001). The interactive effect of CTRP3 showed a significant increase in the post-test between controls and the combined training groups (p=0.001) and the highest increase of CTRP3 was in aerobic-resistance group (p=0.004). There was no significant difference between the groups despite improvement of insulin resistance index (p=0.08). Conclusion: To conchide, based on the results, the use of combined exercise, especially in the order of aerobic-resistance training, decreased the pro-inflammatory cytokines and increased anti-inflammatory cytokines, combination training is recommended for patients with type 2 diabetes.